Effects of hydroalcoholic extract of Carthamus tinctorius on activity of hepatic transaminases in alloxan - induced diabetic rats

زمینه و هدف: گل گلرنگ (Carthamus tinctorius) غالباً به‌ عنوان رنگ غذا و چاشنی استفاده می‌شود، و در طب سنتی به آن اثراتی از جمله اثرات ضدروماتیسم و ضد دیابت نسبت داده می‌شود. این مطالعه با هدف بررسی اثر عصاره هیدروالکلی گل گلرنگ بر سطح آنزیم‌های آلانین آمینو ترانسفراز (ALT) و آسپارتات آمینو ترانسفراز (AST) در حیوانات دیابتی شده با آلوکسان انجام شد. روش بررسی: در این مطالعه تجربی 18 سر موش صحرایی نر از نژاد ویستار به طور تصادفی در سه گروه شش تایی، غیر دیابتی (گروه 1) دیابتی شده با آلوکسان (گروه 2) و دیابتی تیمار شده با عصاره هیدروالکلی گل گلرنگ به میزان mg/kg 200 به صورت تزریقی داخل صفاقی (گروه 3) تقسیم شدند. قبل از شروع مطالعه دو هفته بعد و شش هفته بعد خونگیری به عمل آمد و سطح آنزیم های آلانین آمینوترانسفراز (ALT) و آسپارتات آمینوترانسفراز (AST) تعیین گردید. نتایج به دست آمده توسط آزمون آماری ANOVA تجزیه و تحلیل شدند. یافته‌ها: قبل از مطالعه سطح آنزیم های آلانین آمینوترانسفراز و آسپارتات آمینوترانسفراز در سه گروه تفاوت معنی داری نداشت. در هفته دوم میزان این آنزیم ها در دو گروه دیابتی بیشتر از گروه شاهد بود (05/0

The effect of hydroalcoholic extracts of Hypericum perforatum and Amaranthus caudatus on rabbits with hypercholesterolemia

چکیده: زمینه و هدف: آترواسکلروز یکی از عوامل مرگ و میر در جهان می باشد. افزایش سطح کلسترول و لیپوپروتئین با دانسیته پایین (LDL) از فاکتورهای خطرزای مهم این بیماری است. این مطالعه با هدف بررسی اثر ضد آترواسکلروزی ترکیب عصاره‌های دو گیاه راعی و تاج‌ خروس در مقایسه با لوستاتین در خرگوش‌های هایپرکلسترولمی‌ انجام شده است. روش بررسی: در این مطالعه تجربی 20 خرگوش نر بالغ از نژاد نیوزیلندی به طور تصادفی در چهار گروه پنج‌تایی تقسیم شدند، این گروهها با رژیم‌های غذایی پایه، پرکلسترول، رژیم پرکلسترول به همراه ترکیب عصاره‌های دو گیاه راعی و تاج ‌خروس هر کدام به طور مساوی با دوز mg/kg75، رژیم پر کلسترول به همراه لواستاتین با دوز mg/kg 10، به مدت 60 روز تیمار شدند. در ابتدا، اواسط و پایان دوره از خرگوش‌ها خون‌گیری بعمل آمد و فاکتورهای سرمی آنها مورد بررسی قرار گرفت. داده ها با استفاده از آزمون های آماری ANOVA و آزمون تعقیبی دانکن تجزیه و تحلیل گردید. یافته ها: نتایج نشان داد که ترکیب عصاره‌ها و همچنین لوستاتین سبب کاهش سطح مالون دی آلدیید (MDA)، آپولیپوپروتئین B، نسبت آپولیپوپروتئین B به آپولیپوپروتئین A، (apoB/apoA) و افزایش سطح آپولیپوپروتئین A نسبت به گروه پرکلسترول می‌گردد (05/0

Endoscopic Arytenoid Abduction Lateropexy with Endolaryngeal Thread Guide Instrument for Bilateral Vocal Fold Paralysis

The treatment of upper airway stenosis is considered to be one of the most difficult fields in laryngology. In the 100-year-old history of airway stenosis surgery several important works of Hungarian authors (Rethi, Lichtenberger, Pytel) are found.At the Department of Oto-Rhino- Laryngology and Head- Neck Surgery, University of Szeged our workgroup has been working on the treatment of upper airway stenosis for more than 30 years.Hereby we introduce our surgical concept for bilateral vocal fold paralysis, the minimally invasive endoscopic arytenoid abduction lateropexy (EAAL), which provides an immediate adequate airway with acceptable voice quality, and good swallow function.A new Endolaryngeal Thread Guide instrument (ETGI) is also presented here, which is essential for a safe, accurate, and fast suture loop creation around the arytenoid cartilage for this surgical procedure

Fractional variational iteration method via modified Riemann–Liouville derivative

AbstractThe aim of this paper is to present an efficient and reliable treatment of the variational iteration method (VIM) for partial differential equations with fractional time derivative. The fractional derivative is described in the Jumarie sense. The obtained results are in good agreement with the existing ones in open literature and it is shown that the technique introduced here is robust, efficient and easy to implement

An integrated approach to simulate gas turbine secondary air system

© 2023 The American Society of Mechanical Engineers. All rights reserved.One of the most critical parts of a modern gas turbine that its reliability and performance has a great influence on cycle efficiency is the secondary air system (SAS). Modern systems functions to supply not only cooling air flow for turbine blades and vanes but sealing flow for bearing chambers and turbine segments as well as turbine disk s' purge flow in order to eliminate hot gas ingestion. Due to the various interactions between SAS and main gas, consideration of the former is substantially crucial in design and analysis of the whole engine. Geometrical complexities and centrifugal effects of rotating blades and disks, however, make the flow field and heat transfer of the problem so complicated AND too computationally costly to be simulated utilizing full 3-D CFD methods. Therefore, developing 1-D and 0-D tools applying network methods are of great interests. The present article describes a modular SAS analysis tool that is consisted of a network of elements and nodes. Each flow branch of a whole engine SAS network is substituted with an element and then, various branches (elements) intersect with each other just at their end nodes. These elements which might include some typical components such as labyrinth seals, orifices, stationary/rotating pipes, pre-swirls, and rim-seals, are generally articulated with characteristic curves that are extracted from high fidelity CFD modeling using commercial software such as Flowmaster or ANSYS-CFX. Having these curves, an algorithm is developed to calculate flow parameters at nodes with the aid of iterative methods. The procedure is based on three main innovative ideas. The first one is related to the network construction by defining a connectivity matrix which could be applied to any arbitrary network such as hydraulic or lubrication networks. In the second one, off-design SAS calculation will be proposed by introducing some SAS elements that their characteristic non-dimensional curves are influenced by their inlet total pressure. The last novelty is the integration of the blades coolant calculation process that incorporates external heat transfer calculation, structural conduction and coolant side modeling with SAS network simulation. Finally, SAS simulation of an industrial gas turbine is presented to illustrate capabilities of the presented tool in design point and off-design conditions

A Comparative Study on the Commentators’ Views Specifying the Concept of Zalalat (Losing the Way) in the Verse “And He Found You Lost So He Guided You”

The Qur'an has applied noble and unique methods to display some arguments; one of the Qur’anic verses in this regard is the seventh verse of the holy Surah az-Zuha. The term “Zal” in this verse being considered as an active participle noun derived from “Zalalat” refers to Prophet Muhammad (PBUH), and it needs to be more accurately researched. The present study simultaneously pursues the conceptual and attributional analysis of the term "Zalalat" in this verse classifying the most significant Sunni and Shi’ite views into two categories. The first one recognizes the attribution of "Zalalat" to the Prophet Muhammad himself stating several aspects to justify the Prophet being lost (Zalalat-e Nabi). In the second category, “Zalalat”, in its various meanings and with mostly literary justifications, refers to the Prophet’s nation. Both of these viewpoints have some drawbacks not being able to answer the ambiguities and questions raised in the mind of the audience especially when confronted with the surface structure of the verse, its context, and the accurate meaning of guidance versus Zalalat. The current research has achieved a selected viewpoint which can be fostered through the Qur’an to the Qur’an exegesis, coherence with the context of the verses, and coordination with theological principles in the realm of prophetic infallibility. The findings of this article can be applied in the Qur’anic studies and exegetical-theological research. Received: 14/5/2018   |   Accepted: 26/10/201

Effects of designed feeding patterns on fatigue in multiple sclerosis patients

زمینه و هدف: بیماری مولتیپل اسکلروزیس (MS) شایع ترین بیماری نورولوژیک در بالغین جوان است که آنها را ناتوان می سازد. خستگی یکی از شایع ترین علائم این بیماری است که نه تنها فعالیت و توانایی بیماران بلکه کیفیت زندگی آنها را نیز کاهش می‌دهد. تغذیه صحیح یکی از روش هایی است که می‌تواند برای کاهش خستگی مورد استفاده قرار گیرد. این مطالعه با هدف بررسی تأثیر الگوی تغذیه‌ای طراحی شده بر خستگی بیماران مولتیپل اسکلروزیس مراجعه کننده به انجمن MS ایران انجام شد. روش بررسی: در این مطالعه نیمه تجربی، 40 بیمار مبتلا به مولتیپل اسکلروزیس به روش نمونه گیری هدفمند و در دسترس انتخاب شدند. ابزار گردآوری داده ها، پرسشنامه محقق ساخته بود. آموزش رعایت الگوی غذایی به مدت 12 هفته بر روی بیماران انجام شد. پرسشنامه ها توسط بیماران قبل و بعد از مداخله تکمیل گردیدند. آنالیز داده ها با استفاده از شاخص های توصیفی (میانگین، انحراف معیار) و آمار استنباطی نظیرt زوجی، انجام شد. یافته ها: میانگین سنی نمونه های مورد مطالعه 5/1 ± 8/35 سال بود. میانگین شدت خستگی نمونه های مورد پژوهش قبل از مطالعه 77/0 ± 9/14 و بعد از رعایت الگوی غذایی 44/0 ± 6/25 بود که نشان می دهد شدت خستگی کاهش معنی داری داشته است (001/0>P). نتیجه گیری: الگوی غذایی ارائه شده در این مطالعه به عنوان یک روش ساده، ارزان، بدون عارضه و غیر تهاجمی برای کاهش خستگی بیماران مبتلا به مولتیپل اسکلروزیس موثر و قابل استفاده است

Superpulsed CO 2

Background. Periorbital basal cell carcinoma (BCC) is considered a high risk case because it is associated with high rate of recurrence and complication. Superpulsed CO2 laser with intraoperative pathologic assessment could be an alternative and appropriate treatment for periocular lesions where Mohs micrographic surgery is not available. Objective. To evaluate the efficacy of superpulsed CO2 laser therapy with intraoperative pathologic assessment on periocular BCC involving eyelash line. Method. This follow-up study was performed on 20 patients with a total of 21 BCC lesions that were pathologically documented. Firstly, debulkation of tumoral mass was done by curettage. Then, irradiation and intraoperative pathologic evaluation were done by concurrent CO2 laser. The patients were followed up for a period of 36 months. Results. Out of 21 lesions, the nodular type accounted for 15 (71.4%) lesions, and 12 (57.1%) lesions were seen in the lower lid as the most common clinical type and site involvement. Twenty BCC lesions (95.2%) were treated after one session. Damage to eyelash was seen in 2 (10%) patients, but ectropion and other complications were not seen in any patient. Conclusion. Treatment with superpulsed CO2 laser and intraoperative pathologic evaluation for periorbital BCC lesions much close to conjunctiva could be an effective method with minimal complications without major danger of recurrence. This modality can be used with care in the inner canthus and high risk pathologic lesions

The effects of hydroalcoholic extract of Artemisia aucheri on bleomycin induced pulmonary fibrosis in rats

Background and aim: Pulmonary fibrosis is one of common side effect of bleomycin, which is administered as a chemotherapeutic agent. Current evidence suggests that reactive oxygen species (ROS) may play a key role in the development of pulmonary fibrosis. This study was designed to investigate the effects of hydroalcoholic extract of Artemisia aucheri with some antioxidant effects on bleomycin induced pulmonary fibrosis in rats. Methods: In this experimental study, thirty five Sprague Dawley rats were semi randomly divide into five groups of seven. In four groups of animals bleomycin sulfate (5 mg/Kg) was used for intra-trachea instillation. Two groups of animals received 100 and 200 mg/kg (i.p) Artemisia aucheri extracts (AAE) and one group received vitamin E (10mg/kg, i.p.) for two weeks. Same amount of saline was administered to the control group. At the end of experimental period, malondialdehyde (MAD) and total antioxidant capacity (T-AOC) serum levels were determined. Lung tissue samples from the all animals were collected for histological investigation. Results: Treatment by AAE and Vitamin E caused decrease in the serum levels of malondialdehyde (MAD) which were not significant, whereas a significant increase was observed in the serum level of total antioxidant capacity. Discussion: The findings of this study suggest that antioxidant compounds of AAE may have therapeutic effect for pulmonary fibrosis